This medicine won't take the spot of finding adequate sleep. It shouldn't be used for occasional sleepiness which includes not been diagnosed as narcolepsy, sleep apnea, or shift do the job snooze problems. Request your medical doctor for tips about superior sleep behavior. If you have slumber apnea and make use of a ongoing optimistic airway tension (CPAP) machine at night, go on working with this equipment with modafinil.
Inhibition of platelet aggregation by clopidogrel is solely resulting from an active metabolite. Clopidogrel is metabolized to this Energetic metabolite in part by CYP2C19. .
Other Clinical Issues The existence of other medical problems may possibly influence the use of this drugs. You should definitely convey to your medical doctor For those who have any other health care challenges, In particular:
When you're getting this medicine, it is particularly essential that the healthcare Experienced know When you are using any of your medicines outlined under. The subsequent interactions have already been selected on The premise in their possible significance and are not necessarily all-inclusive.
Belzutifan is actually a CYP2C19 substrate. Coadministration with CYP2C19 inhibitors may possibly boost incidence or severity of adverse consequences. Watch for anemia and hypoxia and minimize belzutifan dose as recommended.
Minor (one)modafinil will boost the degree or effect of pantoprazole by affecting hepatic enzyme CYP2C19 metabolism. Insignificant/Significance Mysterious. Net effect on pantoprazole steps mysterious as a consequence of opposing effects of CYP450 enzymes; watch
It had been clinically uncovered that modafinil affects pharmacodynamics of medication which happen to be metabolized by more information CYP3A4 and also other enzymes of the cytochrome P450 family, in order that interactions of modafinil with these drugs were noticed in genuine people, as opposed to staying predicted inside of a lab location.
In addition to its required consequences, a medicine may perhaps trigger some undesired effects. Whilst not most of these Negative effects may come about, should they do arise they may will need healthcare consideration.
steroid hormones, which include estradiol, progesterone or cortisol. Modafinil may have an adverse impact on hormonal contraceptives (such as birth Command pills, patches, etcetera.) for up to per month just after discontinuation.[133] Both of those modafinil and armodafinil in The usa and the uk feature deal inserts that spotlight the conversation among these drugs and hormonal beginning Management.[86] Modafinil might induce cytochrome P450 enzymes which can be involved in the clearance of steroid hormones taken as hormonal contraceptives, reducing their performance, which can result in pregnancy Regardless of taking the delivery Regulate medication.
Keep an eye on Intently (1)levoketoconazole will raise the amount or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Stiripentol is usually a CYP3A4 inhibitor and inducer. Observe CYP3A4 substrates coadministered with stiripentol for greater or diminished results. CYP3A4 substrates might require dosage adjustment.
rifapentine will lower the level or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Modafinil affects the central anxious method. This medication may impair your considering or reactions. Be mindful for those who push or do something that needs you to be notify. Steer clear of other risky actions right up until you know how this medication will have an affect on your amount of wakefulness.
cenobamate will enhance the level or effect of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Check Carefully. Think about a dose reduction of CYP2C19 substrates, as clinically correct, when used concomitantly with cenobamate.